PedSurg Resource
Cancer Committee
Introduction
The mission of the APSA Cancer Committee is to educate the APSA membership on the current approaches to the treatment of children with cancer, as directed by the Children’s Oncology Group (COG), and to update the membership on new COG protocols and changes to existing ones. The mission also includes informing the membership of recent advances in pediatric oncology, both clinical and basic science. The primary vehicles for accomplishing this mission of education are the APSA newsletter, the APSA-COG website link, the COG session at the annual APSA meeting and the quadrennial pediatric surgical oncology conference held together with our international colleagues in the International Society of Pediatric Surgical Oncology (IPSO) at the Spring APSA meeting.
The members of the committee are listed on the Cancer Committee page on apsapedsurg.org.
Handbooks
Each handbook identifies APSA members who have extensive knowledge with this disease process and contains a one-minute review (to refresh just before an operation), staging materials, surgical management and other necessary information on this cancer. These handbooks are provided by the APSA Cancer Committee and will be periodically updated to provide current standards of care for treatment. These handbooks are not meant to replace involvement with Children’s Oncology Group protocols and continued participation in COG activities is strongly encouraged.
Link to the APSA cancer committee handbooks.
Videos
video link to the APSA 2020 virtual meeting Cancer committee session on Complicated Wilms Tumor
video link to the APSA 2020 virtual meeting Cancer committee session on Technical Challenges in Rhabdomyosarcoma
video link to Muscle Sparing Thoracotomy
Additional Resources
Cancer committee articles of interest
NIH National Cancer Institute (NCI) PDQ® Pediatric Cancer Treatment Summaries
PDQ (Physician Data Query) is NCI’s comprehensive source of cancer information. It contains cancer information summaries on a wide range of cancer topics, drug information summaries on many cancer related drugs and drug combinations and dictionaries of general cancer terms, drug terms and genetics terms. PDQ summaries area available for many common pediatric malignancies.
National Comprehensive Cancer Network (NCCN) Guidelines
The National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology (NCCN Guidelines®) document evidence-based, consensus-driven management to ensure that all patients receive preventive, diagnostic, treatment and supportive services that are most likely to lead to optimal outcomes. While generally geared to adult patients, these guidelines are a useful resource when caring for children and adolescents with malignancies which more commonly effect adults. NCCN Guidelines are free to access but do require you to create a log in.
Pediatric Surgery Not a Textbook
Designed for both practicing and in-training pediatric surgeons, the Pediatric Surgery Not a Textbook (NaT) is updated quarterly so you will know what strategies, techniques and procedures are being used right now. It is written for pediatric surgeons by pediatric surgeons and contains learning objectives, images, videos and links to continuous certification CME and the medical literature. To take advantage of CME you also need to be subscribed to ExPERT. Access to the Pediatric Surgery NaT is by subscription.
Additional resources by tumor type
Adrenocortical carcinoma
Adrenal Cortical Tumors in the NaT
Breast cancer
Breast Disorders in the NaT
Colorectal cancer
NCCN Guidelines – adult rectal
Ewing sarcoma
Ewing Sarcoma of the Chest Wall in the NaT
Gastric tumors
Gastric Tumors in the NaT
Germ cell tumors
Sacrococcygeal Teratoma in the NaT
Germ Cell Ovarian Tumors in the NaT
Testicular Tumors in the NaT
Hepatic tumors (nonhepatoblastoma)
Hepatocellular Carcinoma in the NaT
Hepatoblastoma
Hepatoblastoma in the NaT
Lymphoma
Lymphoma in the NaT
Melanoma
Sentinel Lymph Node Biopsy in the NaT
Neuroblastoma
Neuroblastoma in the NaT
Neuroendocrine tumors
Nonrhabdomyosarcoma soft tissue sarcoma
Nonrhabdomyosarcoma Soft Tissue Sarcoma in the NaT
Ovarian cancer (nongerm cell)
Ovarian Tumors in the NaT
Osteosarcoma
Pulmonary Metastatic Disease in the NaT
Pancreatic tumors
Pancreatic Tumors in the NaT
NCCN Guidelines – adult Pancreatic Adenocarcinoma
Pheochromocytoma and paraganglioma
Adrenal Medullary Tumors in the NaT
Pleuropulmonary blastoma
Renal cell carcinoma
Renal Cell Carcinoma in the NaT
NCI PDQ – adult Transitional Cell
Renal tumors (nonWilms, nonrenal cell carcinoma)
Mesoblastic Nephroma in the NaT
Rhabdomyosarcoma
Rhabdomyosarcoma in the NaT
Rhabdomyosarcoma of the Chest Wall in the NaT
Paratesticular Rhabdomyosarcoma in the NaT
Testicular cancer (nongerm cell)
Testicular Tumors in the NaT
Thyroid cancer
Malignant Thyroid Tumors in the NaT
Wilms tumor
Wilms Tumor in the NaT
References
- Appel BE, Chen L, Buxton AB, et al. Minimal Treatment of Low-Risk, Pediatric Lymphocyte-Predominant Hodgkin Lymphoma: A Report From the Children's Oncology Group. J Clin Oncol. 2016;34(20):2372-9. [PMID:27185849]
- Aronson DC, Weeda VB, Maibach R, et al. Microscopically positive resection margin after hepatoblastoma resection: what is the impact on prognosis? A Childhood Liver Tumours Strategy Group (SIOPEL) report. Eur J Cancer. 2019;106:126-132. [PMID:30528797]
- Brecht IB, De Paoli A, Bisogno G, et al. Pediatric patients with cutaneous melanoma: A European study. Pediatr Blood Cancer. 2018;65(6):e26974. [PMID:29350487]
- Dika E, Ravaioli GM, Fanti PA, et al. Spitz Nevi and Other Spitzoid Neoplasms in Children: Overview of Incidence Data and Diagnostic Criteria. Pediatr Dermatol. 2017;34(1):25-32. [PMID:27874206]
- Faries MB, Thompson JF, Cochran AJ, et al. Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma. N Engl J Med. 2017;376(23):2211-2222. [PMID:28591523]
- Francis GL, Waguespack SG, Bauer AJ, et al. Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid. 2015;25(7):716-59. [PMID:25900731]
- Kim J, Sun Z, Adam MA, et al. Predictors of nodal metastasis in pediatric differentiated thyroid cancer. J Pediatr Surg. 2017;52(1):120-123. [PMID:27836371]
- Laverdière C, Liu Q, Yasui Y, et al. Long-term outcomes in survivors of neuroblastoma: a report from the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2009;101(16):1131-40. [PMID:19648511]
- Lindholm EB, Alkattan AK, Abramson SJ, et al. Pancreaticoduodenectomy for pediatric and adolescent pancreatic malignancy: A single-center retrospective analysis. J Pediatr Surg. 2017;52(2):299-303. [PMID:27894759]
- Mansfield SA, Mahida JB, Dillhoff M, et al. Pancreaticoduodenectomy outcomes in the pediatric, adolescent, and young adult population. J Surg Res. 2016;204(1):232-6. [PMID:27451891]
- Meyers RL, Maibach R, Hiyama E, et al. Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic tumors International Collaboration. Lancet Oncol. 2017;18(1):122-131. [PMID:27884679]
- Morton DL, Thompson JF, Cochran AJ, et al. Final trial report of sentinel-node biopsy versus nodal observation in melanoma. N Engl J Med. 2014;370(7):599-609. [PMID:24521106]
- Moskowitz CS, Chou JF, Wolden SL, et al. Breast cancer after chest radiation therapy for childhood cancer. J Clin Oncol. 2014;32(21):2217-23. [PMID:24752044]
- O'Neill AF, Towbin AJ, Krailo MD, et al. Characterization of Pulmonary Metastases in Children With Hepatoblastoma Treated on Children's Oncology Group Protocol AHEP0731 (The Treatment of Children With All Stages of Hepatoblastoma): A Report From the Children's Oncology Group. J Clin Oncol. 2017;35(30):3465-3473. [PMID:28892430]
- Oeffinger KC, Mertens AC, Sklar CA, et al. Chronic health conditions in adult survivors of childhood cancer. N Engl J Med. 2006;355(15):1572-82. [PMID:17035650]
- Ronceray L, Abla O, Barzilai-Birenboim S, et al. Children and adolescents with marginal zone lymphoma have an excellent prognosis with limited chemotherapy or a watch-and-wait strategy after complete resection. Pediatr Blood Cancer. 2018;65(4). [PMID:29286565]
- Ruhlmann M, Ruhlmann J, Görges R, et al. 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography May Exclude Malignancy in Sonographically Suspicious and Scintigraphically Hypofunctional Thyroid Nodules and Reduce Unnecessary Thyroid Surgeries. Thyroid. 2017;27(10):1300-1306. [PMID:28793848]
- Skinner MA, Moley JA, Dilley WG, et al. Prophylactic thyroidectomy in multiple endocrine neoplasia type 2A. N Engl J Med. 2005;353(11):1105-13. [PMID:16162881]
- Tang AL, Falciglia M, Yang H, et al. Validation of American Thyroid Association Ultrasound Risk Assessment of Thyroid Nodules Selected for Ultrasound Fine-Needle Aspiration. Thyroid. 2017;27(8):1077-1082. [PMID:28657511]
- Towbin AJ, Meyers RL, Woodley H, et al. 2017 PRETEXT: radiologic staging system for primary hepatic malignancies of childhood revised for the Paediatric Hepatic International Tumour Trial (PHITT). Pediatr Radiol. 2018;48(4):536-554. [PMID:29427028]
- Turcotte LM, Liu Q, Yasui Y, et al. Temporal Trends in Treatment and Subsequent Neoplasm Risk Among 5-Year Survivors of Childhood Cancer, 1970-2015. JAMA. 2017;317(8):814-824. [PMID:28245323]
- Wells SA, Asa SL, Dralle H, et al. Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma. Thyroid. 2015;25(6):567-610. [PMID:25810047]
- Wong KF, Reulen RC, Winter DL, et al. Risk of Adverse Health and Social Outcomes Up to 50 Years After Wilms Tumor: The British Childhood Cancer Survivor Study. J Clin Oncol. 2016;34(15):1772-9. [PMID:27022116]
- Wong SL, Faries MB, Kennedy EB, et al. Sentinel Lymph Node Biopsy and Management of Regional Lymph Nodes in Melanoma: American Society of Clinical Oncology and Society of Surgical Oncology Clinical Practice Guideline Update. Ann Surg Oncol. 2018;25(2):356-377. [PMID:29236202]
- d'Ambrosio G, del Prete L, Grimaldi C, et al. Pancreaticoduodenectomy for malignancies in children. J Pediatr Surg. 2014;49(4):534-8. [PMID:24726107]
