Mediastinal Germ Cell Tumors
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Mediastinal tumors comprise four percent of all germ cell tumors and six to 20% of all mediastinal masses seen in children . Germ cell tumors are secondary in incidence in the mediastinum to neurogenic tumors and lymphomas.
Age and gender play an important role in the behavior of mediastinal germ cell tumors. These tumors have been reported from newborns to adulthood. However, mediastinal germ cell tumors are most common in adolescents . In childhood, these tumors are often benign. Conversely, in adolescence they often display aggressive behavior or contain malignant elements . In infancy and childhood, incidence of malignant germ cell tumors (MGCT) is slightly higher for female patients, whereas the incidence of MGCT is slightly higher for male patients in adolescence . The overall malignancy rate is approximately 14% in children and the chance of malignancy is higher in males than females .
see also Extragonadal Germ Cell Tumors
content in this topic is referenced in SCORE Teratoma overview
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Last updated: August 3, 2018
Galganski, Laura, and Rebecca Stark. "Mediastinal Germ Cell Tumors." Pediatric Surgery NaT, American Pediatric Surgical Association, 2018. APSA Webapp, www.pedsurglibrary.com/apsa/view/Pediatric-Surgery-NaT/829790/all/Mediastinal_Germ_Cell_Tumors.
Galganski L, Stark R. Mediastinal Germ Cell Tumors. In: Waldhausen J, Powell D, Hirschl R, eds. Pediatric Surgery NaT. American Pediatric Surgical Association; 2018. https://www.pedsurglibrary.com/apsa/view/Pediatric-Surgery-NaT/829790/all/Mediastinal_Germ_Cell_Tumors. Accessed April 21, 2019.
Galganski, L., & Stark, R. (2018). Mediastinal Germ Cell Tumors. In Waldhausen, J., Powell, D., & Hirschl, R. (Eds.), Pediatric Surgery NaT. Available from https://www.pedsurglibrary.com/apsa/view/Pediatric-Surgery-NaT/829790/all/Mediastinal_Germ_Cell_Tumors
Galganski L, Stark R. Mediastinal Germ Cell Tumors [Internet]. In: Waldhausen J, Powell D, Hirschl R, editors. Pediatric Surgery NaT. American Pediatric Surgical Association; 2018. [cited 2019 April 21]. Available from: https://www.pedsurglibrary.com/apsa/view/Pediatric-Surgery-NaT/829790/all/Mediastinal_Germ_Cell_Tumors.
TY - ELEC
T1 - Mediastinal Germ Cell Tumors
ID - 829790
A1 - Galganski,Laura,MD
AU - Stark,Rebecca,MD
ED - Waldhausen,John,
ED - Powell,David,
ED - Hirschl,Ron,
Y1 - 2018/08/03/
BT - Pediatric Surgery NaT
UR - https://www.pedsurglibrary.com/apsa/view/Pediatric-Surgery-NaT/829790/all/Mediastinal_Germ_Cell_Tumors
PB - American Pediatric Surgical Association
DB - APSA Webapp
DP - Unbound Medicine