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Neutropenic Enterocolitis

Neutropenic Enterocolitis is a topic covered in the Pediatric Surgery NaT.

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Neutropenic enterocolitis (NE) is characterized by fever and abdominal pain in a neutropenic patient. NE was originally described in children with acute leukemia who had undergone induction chemotherapy. Various names have been given to this disease including typhlitis, neutropenic colitis, necrotizing enterocolitis, ileocecal syndrome and cecitis.

NE is recognized as a significant cause of morbidity and mortality in immunocompromised patients. A high index of suspicion and early diagnosis are paramount. Initial therapy is focused on medical management to halt the disease process. Surgery is reserved for severe complications. Much work is needed to better understand the pathophysiology, prevention and optimal treatment of NE.

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Last updated: March 19, 2018


Waldhausen, John, et al., editors. "Neutropenic Enterocolitis." Pediatric Surgery NaT, American Pediatric Surgical Association, 2018. APSA Webapp, www.pedsurglibrary.com/apsa/view/Pediatric-Surgery-NaT/829142/all/Neutropenic_Enterocolitis.
Neutropenic Enterocolitis. In: Waldhausen J, Powell D, Hirschl R, eds. Pediatric Surgery NaT. American Pediatric Surgical Association; 2018. https://www.pedsurglibrary.com/apsa/view/Pediatric-Surgery-NaT/829142/all/Neutropenic_Enterocolitis. Accessed June 16, 2019.
Neutropenic Enterocolitis. (2018). In Waldhausen, J., Powell, D., & Hirschl, R. (Eds.), Pediatric Surgery NaT. Available from https://www.pedsurglibrary.com/apsa/view/Pediatric-Surgery-NaT/829142/all/Neutropenic_Enterocolitis
Neutropenic Enterocolitis [Internet]. In: Waldhausen J, Powell D, Hirschl R, editors. Pediatric Surgery NaT. American Pediatric Surgical Association; 2018. [cited 2019 June 16]. Available from: https://www.pedsurglibrary.com/apsa/view/Pediatric-Surgery-NaT/829142/all/Neutropenic_Enterocolitis.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Neutropenic Enterocolitis ID - 829142 ED - Waldhausen,John, ED - Powell,David, ED - Hirschl,Ron, Y1 - 2018/03/19/ BT - Pediatric Surgery NaT UR - https://www.pedsurglibrary.com/apsa/view/Pediatric-Surgery-NaT/829142/all/Neutropenic_Enterocolitis PB - American Pediatric Surgical Association DB - APSA Webapp DP - Unbound Medicine ER -