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The pathophysiology of inhalation injury is multifactorial. Direct thermal injury accounts for the trauma to the supraglottic region while chemical and particulate constituents of smoke contribute to the damage caused to the tracheobronchial tree and lung parenchyma. The chemical injury initiates a series of events which include the release of inflammatory mediators with subsequent increased permeability leading to edema, mucosal sloughing and cast formation. This can manifest clinically as bronchospasm, small airway occlusion and decreased pulmonary compliance all which contribute to respiratory failure .
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Last updated: May 5, 2016
González, Raquel. "Inhalation Injury." Pediatric Surgery NaT, American Pediatric Surgical Association, 2016. APSA Webapp, www.pedsurglibrary.com/apsa/view/Pediatric-Surgery-NaT/829115/all/Inhalation_Injury.
González R. Inhalation Injury. In: Waldhausen J, Powell D, Hirschl R, eds. Pediatric Surgery NaT. American Pediatric Surgical Association; 2016. https://www.pedsurglibrary.com/apsa/view/Pediatric-Surgery-NaT/829115/all/Inhalation_Injury. Accessed November 21, 2019.
González, R. (2016). Inhalation Injury. In Waldhausen, J., Powell, D., & Hirschl, R. (Eds.), Pediatric Surgery NaT. Available from https://www.pedsurglibrary.com/apsa/view/Pediatric-Surgery-NaT/829115/all/Inhalation_Injury
González R. Inhalation Injury [Internet]. In: Waldhausen J, Powell D, Hirschl R, editors. Pediatric Surgery NaT. American Pediatric Surgical Association; 2016. [cited 2019 November 21]. Available from: https://www.pedsurglibrary.com/apsa/view/Pediatric-Surgery-NaT/829115/all/Inhalation_Injury.
TY - ELEC
T1 - Inhalation Injury
ID - 829115
A1 - González,Raquel,MD, MHCM
ED - Waldhausen,John,
ED - Powell,David,
ED - Hirschl,Ron,
Y1 - 2016/05/05/
BT - Pediatric Surgery NaT
UR - https://www.pedsurglibrary.com/apsa/view/Pediatric-Surgery-NaT/829115/all/Inhalation_Injury
PB - American Pediatric Surgical Association
DB - APSA Webapp
DP - Unbound Medicine